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SHP504

Chemical Structure : SHP504

CAS No.: 2222280-83-1

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SHP504 (SHP 504)

Catalog No.: PC-62630Not For Human Use, Lab Use Only.

SHP504 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 21 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SHP504 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 21 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
    SHP504 downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells.
    SHP504 enhances pharmacological pathway inhibition in cells combined with SHP099.

    Physicochemical Properties

    M.Wt 446.847
    Formula C23H15ClN4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-(2-chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)-4-hydroxybenzoic acid

    References

    1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980.

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