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YU142670

Chemical Structure : YU142670

CAS No.: 133847-06-0

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YU142670 (YU 142670)

Catalog No.: PC-62376Not For Human Use, Lab Use Only.

YU142670 is a highly specific, soluble OCRL/INPP5B inhibitor that directly interacts with the catalytic domain of INPP5B.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YU142670 is a highly specific, soluble OCRL/INPP5B inhibitor with IC50 of 0.71 and 1.78 μM in malachite green assay respectively, directly interacts with the catalytic domain of INPP5B.
    YU142670 does not inhibit INPP5A, SHIP1 and SJ1 5-phosphatases.
    YU142670 induces enhanced actin polymerization and ruffle activity at the plasma membrane, increases the levels of PI(4,5)P2 in mouse embryonic fibroblasts or human dermal fibroblasts and inhibits the activity of over-expressed human OCRL in Cos-7 cells.

    Physicochemical Properties

    M.Wt 203.22
    Formula C8H5N5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-Pyridinyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

    References

    1. Pirruccello M, et al. ACS Chem Biol. 2014 Jun 20;9(6):1359-68.

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