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MLS 0263839

Chemical Structure : MLS 0263839

CAS No.: 716375-92-7

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MLS 0263839 (MLS0263839)

Catalog No.: PC-62546Not For Human Use, Lab Use Only.

MLS 0263839 is a potent, specific inhibitor of the phosphatase PHOSPHO1 with IC50 of 0.14 uM, shows minimal cross-inhibition of TNAP and no inhibition of ENPP1 activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MLS 0263839 is a potent, specific inhibitor of the phosphatase PHOSPHO1 with IC50 of 0.14 uM, shows minimal cross-inhibition of TNAP and no inhibition of ENPP1 activity.
    MLS 0263839 suppresses vascular smooth muscle cell calcification in cimbined with MLS 0038949.

    Physicochemical Properties

    M.Wt 334.408
    Formula C15H14N2O3S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N,N-dimethyl-3-(3-oxobenzo[d]isothiazol-2(3H)-yl)benzenesulfonamide

    References

    1. Kiffer-Moreira T, et al. J Bone Miner Res. 2013 Jan;28(1):81-91.

    2. Huesa C, et al. Biochem Biophys Rep. 2015 Dec 1;4:196-201.

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