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ML 086

Chemical Structure : ML 086

CAS No.: 1177148-36-5

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ML 086 (ML086;CID-1674999)

Catalog No.: PC-62547Not For Human Use, Lab Use Only.

ML 086 is a potent, specific inhibitor of phosphatase PHOSPHO1 with IC50 of 139 nM, with no activity against TNAP (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML 086 (ML086) is a potent, specific inhibitor of phosphatase PHOSPHO1 with IC50 of 139 nM, with no activity against TNAP (IC50>100 uM).
    ML 086 is a useful chemical tool to examine the functional role of this enzyme in skeletal mineralization and soft tissue ossification abnormalities.

    Physicochemical Properties

    M.Wt 298.36
    Formula C16H14N2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzamide

    References

    1. Stonich D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

    2. Bravo Y, et al. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4308-11.

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