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SHP844

Chemical Structure : SHP844

CAS No.: 2222280-82-0

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SHP844 (SHP 844)

Catalog No.: PC-62629Not For Human Use, Lab Use Only.

SHP844 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 18.9 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SHP844 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 18.9 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
SHP844 downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells.
SHP844 enhances pharmacological pathway inhibition in cells combined with SHP099.

Physicochemical Properties

M.Wt 573.99
Formula C29H24ClN5O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(3-chloro-4-((1-(2-hydroxy-3-methoxyphenyl)-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl)methyl)benzoyl)-L-proline

References

1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980.

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