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SHP844

Chemical Structure : SHP844

CAS No.: 2222280-82-0

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SHP844 (SHP 844)

Catalog No.: PC-62629Not For Human Use, Lab Use Only.

SHP844 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 18.9 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SHP844 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 18.9 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
    SHP844 downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells.
    SHP844 enhances pharmacological pathway inhibition in cells combined with SHP099.

    Physicochemical Properties

    M.Wt 573.99
    Formula C29H24ClN5O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-chloro-4-((1-(2-hydroxy-3-methoxyphenyl)-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl)methyl)benzoyl)-L-proline

    References

    1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980.

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