Catalog No.: PC-62679Not For Human Use, Lab Use Only.
NSC 663284 (SPS8I1, DA3003-1) is a potent inhibitor of the dual specificity protein phosphatase Cdc25 with Ki of 9/95//89 nM for Cdc25A/Cdc25B2/Cdc25C, also inhibits NSD2 catalytic SET domain with IC50/Ki of 170/370 nM.
NSC 663284 (SPS8I1, DA3003-1) is a potent inhibitor of the dual specificity protein phosphatase Cdc25 with Ki of 9/95//89 nM for Cdc25A/Cdc25B2/Cdc25C, also inhibits NSD2 catalytic SET domain with IC50/Ki of 170/370 nM.
NSC 663284 displays 20- and 450-fold more selective over VHR or PTP1B phosphatases.
NSC 663284 (SPS8I1, DA3003-1) blocks cellular Erk dephosphorylation caused by ectopic Cdc25A expression.
NSC 663284 (SPS8I1, DA3003-1) also shows to be a potent and selective SETD8 inhibitor with apparent IC50 of 0.21 uM.
NSC 663284 (SPS8I1, DA3003-1) shows 2.5-fold lower than SMYD2, >6-fold lower than other PMTs (IC50=1.3-100 uM).
