Catalog No.: PC-62631Not For Human Use, Lab Use Only.
SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells.
SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
SHP836 downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells。
SHP836 enhances pharmacological pathway inhibition in cells combined with SHP099.
