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DPM-1001

Chemical Structure : DPM-1001

CAS No.: 1471172-27-6

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DPM-1001 (DPM1001)

Catalog No.: PC-62543Not For Human Use, Lab Use Only.

DPM-1001 is a potent, selective, orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B with IC50 of 100 nM, also chelates copper, which enhanced its potency as a PTP1B inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DPM-1001 is a potent, selective, orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B with IC50 of 100 nM, also chelates copper, which enhanced its potency as a PTP1B inhibitor.
    DPM-1001 displays anti-diabetic properties associated with enhanced signaling through insulin and leptin receptors in animal models of diet-induced obesity.

    Physicochemical Properties

    M.Wt 567.859
    Formula C35H57N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl (R)-4-((3S,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-((4-((pyridin-2-ylmethyl)amino)butyl)amino)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

    References

    1. Krishnan N, et al. J Biol Chem. 2018 Feb 2;293(5):1517-1525.

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