Catalog No.: PC-62545Not For Human Use, Lab Use Only.
MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM).
MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM).
MLS 0038949 suppresses vascular smooth muscle cell calcification combined with PHOSPHO1 inhibitor MLS-0263839.
MLS 0038949 eliminates AMP hydrolysis in DRG and spinal lamina II of dKO mice.
Physicochemical Properties
M.Wt
344.385
Formula
C17H16N2O4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide
References
1. Street SE, et al. J Neurosci. 2013 Jul 3;33(27):11314-22.
2. Kiffer-Moreira T, et al. J Bone Miner Res. 2013 Jan;28(1):81-91.
3. Dahl R, et al. J Med Chem. 2009 Nov 12;52(21):6919-25.
