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MLS 0038949

Chemical Structure : MLS 0038949

CAS No.: 496014-13-2

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MLS 0038949 (MLS0038949)

Catalog No.: PC-62545Not For Human Use, Lab Use Only.

MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM).
    MLS 0038949 suppresses vascular smooth muscle cell calcification combined with PHOSPHO1 inhibitor MLS-0263839.
    MLS 0038949 eliminates AMP hydrolysis in DRG and spinal lamina II of dKO mice.

    Physicochemical Properties

    M.Wt 344.385
    Formula C17H16N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide

    References

    1. Street SE, et al. J Neurosci. 2013 Jul 3;33(27):11314-22.

    2. Kiffer-Moreira T, et al. J Bone Miner Res. 2013 Jan;28(1):81-91.

    3. Dahl R, et al. J Med Chem. 2009 Nov 12;52(21):6919-25.

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