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NSC45586

Chemical Structure : NSC45586

CAS No.: 6300-44-3

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NSC45586 (NCI 45586 sodium salt, NSC 45586)

Catalog No.: PC-60663Not For Human Use, Lab Use Only.

NSC45586 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NSC45586 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
NSC45586 also inhibits PHLPP2, has no activities against other phosphatases.
NSC45586 activates AKT and ameliorates staurosporine-induced cell death in neurons.

Physicochemical Properties

M.Wt 412.385
Formula C20H17N6NaO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

benzoic acid, 5-[2-[4-[2-(2,4-diamino-5-methylphenyl)diazenyl]phenyl]diazenyl]-2-hydroxy-,sodium salt

References

1. Jackson TC, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.

2. Sierecki E, et al. J Med Chem. 2010 Oct 14;53(19):6899-911.

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