ATUX-1215 | PP2A activator | Probechem Biochemicals

Chemical Structure : ATUX-1215

ATUX-1215 (ATUX1215)

Catalog No.: PC-21366Not For Human Use, Lab Use Only.

ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo.

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Biological Activity

ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo.
ATUX-1215 (1 uM) induces PP2A phosphatase activity responses in fibroblasts, reduced the level of TGFβ induction of ACTA2, COL1A1, COL1A2, and FN1 gene expression in fibroblasts.
ATUX-1215 activates PP2A responses in the BLM model and elicited potentially useful therapeutic effects.
ATUX-1215 (5 mg/kg, daily, oral) reduces the BLM-induced BALF levels of IL12p70, GM-CSF, and IL-1α in C57BL/6J mice.
ATUX-1215 shows the improved metabolic stability and bioavailability of ATUX-1215 to previously described PP2A activators.
ATUX-1215 prevents BLM-induced lung physiology changes, including the preservation of normal PV loop, compliance, tissue elastance, and forced vital capacity.

Physicochemical Properties

M.Wt	553.54
Formula	C27H24F5NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, N-[(2R,4S)-2-(2,8-difluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)tetrahydro-2H-pyran-4-yl]-4-(trifluoromethoxy)-

References

1. Meshach Pillai, et al. ACS Pharmacol Transl Sci. 2023 Oct 17;6(11):1659-1672.

ATUX-1215 (ATUX1215)

Biological Activity

Physicochemical Properties

References

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