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Chemical Structure : II-B08
Catalog No.: PC-61276Not For Human Use, Lab Use Only.
II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.
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II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.
II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation.
II-B08 exhibits marked anti-tumor activity in H1975 xenograft mice.
| M.Wt | 557.61 | |
| Formula | C33H27N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nabinger SC, et al. Leukemia. 2013 Feb;27(2):398-408.
2. Zhang X, et al. J Med Chem. 2010 Mar 25;53(6):2482-93.
3. Xu J, et al. Biochem Biophys Res Commun. 2013 Oct 4;439(4):586-90.
4. Sharma N, et al. Oncotarget. 2014 Aug 15;5(15):6130-41.
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