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II-B08

Chemical Structure : II-B08

CAS No.: 1143579-78-5

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II-B08 (SHP2 inhibitor II-B08)

Catalog No.: PC-61276Not For Human Use, Lab Use Only.

II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    II-B08 is a potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.
    II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation.
    II-B08 exhibits marked anti-tumor activity in H1975 xenograft mice.

    Physicochemical Properties

    M.Wt 557.61
    Formula C33H27N5O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid

    References

    1. Nabinger SC, et al. Leukemia. 2013 Feb;27(2):398-408.

    2. Zhang X, et al. J Med Chem. 2010 Mar 25;53(6):2482-93.

    3. Xu J, et al. Biochem Biophys Res Commun. 2013 Oct 4;439(4):586-90.

    4. Sharma N, et al. Oncotarget. 2014 Aug 15;5(15):6130-41.

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