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BN82002 hydrochloride

Chemical Structure : BN82002 hydrochloride

CAS No.: 1049740-43-3

BN82002 hydrochloride

Catalog No.: PC-22998Not For Human Use, Lab Use Only.

BN82002 hydrochloride is a potent Cdc25 dual specificity phosphatase inhibitor with IC50 of 2-6 uM for Cdc25A/B/C.

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Biological Activity

BN82002 hydrochloride is a potent Cdc25 dual specificity phosphatase inhibitor with IC50 of 2-6 uM for Cdc25A/B/C.
BN82002 impairs the proliferation of tumoral cell lines and increases CDK1 inhibitory tyrosine phosphorylation, delays cell cycle progression in HeLa cells;.
BN82002 reduces growth rate of human tumor xenografts in mice.

Physicochemical Properties

M.Wt 395.88
Formula C19H26ClN3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Phenol, 4-(dimethylamino)-2-methoxy-6-[[methyl[2-(4-nitrophenyl)ethyl]amino]methyl]-, hydrochloride (1:1)

References

1. Brezak MC, et al. Cancer Res. 2004 May 1;64(9):3320-5.

2. Contour-Galcéra MO, et al. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12.

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