PTPN22 inhibitor 8b

Chemical Structure : PTPN22 inhibitor 8b

Catalog No.: PC-23638Not For Human Use, Lab Use Only.

PTPN22 inhibitor 8b is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase (LYP, PTPN22) with Ki/IC50 of 110/260 nM, > 9-fold selectivity over a large panel of PTPs.

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Biological Activity

PTPN22 inhibitor 8b is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase (LYP, PTPN22) with Ki/IC50 of 110/260 nM, > 9-fold selectivity over a large panel of PTPs.
PTPN22 inhibitor 8b possesses highly efficacious cellular activity in both T- and mast cells and is capable of blocking anaphylaxis in mice.

Physicochemical Properties

M.Wt	501.92
Formula	C28H20ClNO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Benzofurancarboxylic acid, 3-[2-(3-chlorophenyl)ethynyl]-2-[4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]-6-hydroxy-

References

1. He Y, et al. J Med Chem. 2013 Jun 27;56(12):4990-5008.

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