Chemical Structure : SMIP-031
CAS No.:
SMIP-031
(SMIP031)
Catalog No.: PC-22546Not For Human Use, Lab Use Only.
SMIP-031 is a potent small molecule inhibitor of metal-dependent phosphatase PPM1A with IC50 of 180 nM, efficiently activates autophagy and reduces the mycobacterium tuberculosis (Mtb) infection.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SMIP-031 is a potent small molecule inhibitor of metal-dependent phosphatase PPM1A with IC50 of 180 nM, efficiently activates autophagy and reduces the mycobacterium tuberculosis (Mtb) infection.
SMIP-031 efficiently increased the level of phosphorylation of S403-p62 and the expression of LC3B-II to activate autophagy, resulting in the dose-dependent clearance of Mtb in infected macrophages.
SMIP-031 possesses a good pharmacokinetic profile and oral bioavailability (F = 74%).
SMIP-031 is well tolerated up to 50 mg/kg and significantly reduces the bacteria burden in the spleens of infected mice.
Physicochemical Properties
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M.Wt
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366.23
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Formula
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C17H17BrFNO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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8-Ethoxy-2-fluoro-5-(2-hydroxyethyl)phenanthridin-5-ium bromide
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References
1. Zhipeng Yu, et al. J Med Chem. 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00513.
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