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Chemical Structure : SMIP-031
Catalog No.: PC-22546Not For Human Use, Lab Use Only.
SMIP-031 is a potent small molecule inhibitor of metal-dependent phosphatase PPM1A with IC50 of 180 nM, efficiently activates autophagy and reduces the mycobacterium tuberculosis (Mtb) infection.
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SMIP-031 is a potent small molecule inhibitor of metal-dependent phosphatase PPM1A with IC50 of 180 nM, efficiently activates autophagy and reduces the mycobacterium tuberculosis (Mtb) infection.
SMIP-031 efficiently increased the level of phosphorylation of S403-p62 and the expression of LC3B-II to activate autophagy, resulting in the dose-dependent clearance of Mtb in infected macrophages.
SMIP-031 possesses a good pharmacokinetic profile and oral bioavailability (F = 74%).
SMIP-031 is well tolerated up to 50 mg/kg and significantly reduces the bacteria burden in the spleens of infected mice.
| M.Wt | 366.23 | |
| Formula | C17H17BrFNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhipeng Yu, et al. J Med Chem. 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00513.
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