Catalog No.: PC-73091Not For Human Use, Lab Use Only.
JMS-053 (KVX-053) is a potent, selective, reversible, and noncompetitive PTP4A inhibitor with IC50 of 50/53/18 nM for PTP4A1/PTP4A2/PTP4A3, respectively.
JMS-053 (KVX-053) is a potent, selective, reversible, and noncompetitive PTP4A inhibitor with IC50 of 50/53/18 nM for PTP4A1/PTP4A2/PTP4A3, respectively.
JMS-053 demonstrates high specificity against a panel of 25 other phosphatases and 50 kinases.
Pharmacological inhibition of PTP4A3 via JMS-053 normalizes VEGF- and LPS-induced decreases in transendothelial electric resistance (TEER).
JMS-053 inhibits OvCa cell proliferation (A2780 cell IC50=600 nM), spheroid viability, and migration.
JMS-053 inhibits RhoA activation in HeyA8 cells (IC50=0.6 uM) and has antitumor activity, inhibits drug-resistant OvCa tumor growth in vivo.
