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Chemical Structure : JMS-053
CAS No.: 1954650-11-3
Catalog No.: PC-73091Not For Human Use, Lab Use Only.
JMS-053 (KVX-053) is a potent, selective, reversible, and noncompetitive PTP4A inhibitor with IC50 of 50/53/18 nM for PTP4A1/PTP4A2/PTP4A3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $428 | In stock | |
| 50 mg | $998 | In stock | |
| 100 mg | Get quote |
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JMS-053 (KVX-053) is a potent, selective, reversible, and noncompetitive PTP4A inhibitor with IC50 of 50/53/18 nM for PTP4A1/PTP4A2/PTP4A3, respectively.
JMS-053 demonstrates high specificity against a panel of 25 other phosphatases and 50 kinases.
Pharmacological inhibition of PTP4A3 via JMS-053 normalizes VEGF- and LPS-induced decreases in transendothelial electric resistance (TEER).
JMS-053 inhibits OvCa cell proliferation (A2780 cell IC50=600 nM), spheroid viability, and migration.
JMS-053 inhibits RhoA activation in HeyA8 cells (IC50=0.6 uM) and has antitumor activity, inhibits drug-resistant OvCa tumor growth in vivo.
| M.Wt | 256.279 | |
| Formula | C13H8N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione |
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1. McQueeney KE, et al. Oncotarget. 2017 Dec 30;9(9):8223-8240.
2. Salamoun JM, et al. Org Biomol Chem. 2016 Jul 6; 14(27):6398-402.
3. Lazo JS, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):652-662.
4. Czub MP, et al. Mol Pharmacol. 2020 Dec;98(6):648-657.
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