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Chemical Structure : SMIP-30
Catalog No.: PC-72527Not For Human Use, Lab Use Only.
SMIP-30 is a potent and selective inhibitor of PPM1A with IC50 of 1 uM, selectively inhibits the phosphatase activity of PPM1A.
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SMIP-30 is a potent and selective inhibitor of PPM1A with IC50 of 1 uM, selectively inhibits the phosphatase activity of PPM1A.
SMIP-30 shows poor inhibitory activity against closest homolog PPM1B (IC50>30 uM).
SMIP-30 is an uncompetitive inhibitor for PPM1A (Ki=0.84 uM), does not exhibit any cytotoxic effects up to 30 uM in THP-1 macrophages.
SMIP-30 dose-dependently reduces the Mtb burden in infected macrophages, and is well tolerated in vivo and combined with rifampicin reduces Mtb burden in the lungs of infected mice.
SMIP-30 induces LC3B-II expression, activates autophagy in Mtb-infected macrophages in a PPM1A-dependent manner.
SMIP-30 induces a dose-dependent increase in phosphorylation of S403-p62 in WT macrophages.
| M.Wt | 352.203 | |
| Formula | C16H15BrFNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stefania Berton, et al. Cell Chem Biol. 2022 Mar 18;S2451-9456(22)00094-0.
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