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Chemical Structure : NSC45586 free base
Catalog No.: PC-72996Not For Human Use, Lab Use Only.
NSC45586 free base (NCS 45586, NCI45586) is a potent, specific PHLPP2 inhibitor with IC50 of 4 uM, targets the PHLPP2 PP2C domain, suppresses MYC and triggers cell death.
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NSC45586 free base (NCS 45586, NCI45586) is a potent, specific PHLPP2 inhibitor with IC50 of 4 uM, targets the PHLPP2 PP2C domain, suppresses MYC and triggers cell death.
NCI45586 caused increases in the phosphorylation of the downstream substrates GSK3 α/β on Ser21/9 and FoxO1/3α on Thr 24/32.
NCI45586 also induced a robust increase in the activity of Akt in HT29 cells (colon cancer cell line),
NCI45586 also showed suppression of MYC and some activation of AKT in the metastasis-derived DU145 cells.
| M.Wt | 390.403 | |
| Formula | C20H18N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nowak DG, et al. J Cell Biol. 2019 May 15. pii: jcb.201902048. doi: 10.1083/jcb.201902048.
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