Chemical Structure : DT-061
CAS No.:
1809427-19-7
DT-061
(SMAP DT-061;NZ-8-061;DT061)
Catalog No. : PC-70158Not For Human Use, Lab Use Only.
SMAP (DT-061, NZ-8-061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth.
Packing Price Stock Quantity 5 mg $198 In stock 0 1 2 3 4 5 10 mg $298 In stock 0 1 2 3 4 5 25 mg $458 In stock 0 1 2 3 4 5 100 mg $988 In stock 0 1 2 3 4 5 200 mg Get quote 0 1 2 3 4 5 1 g Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
99.03% (HPLC) Select Batch: PC-7015801
Biological Activity
SMAP (DT-061, NZ-8-061) is an orally bioavailable small molecule activator of PP2A , inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A.
Physicochemical Properties
M.Wt
520.523
Formula
C25H23F3N2O5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-((1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide, rel-
References
1. Sangodkar J, et al. J Clin Invest.
2. Kauko O, et al. Sci Transl Med.
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