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CS-11

Chemical Structure : CS-11

CAS No.:

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CS-11 (CS11;CS 11)

Catalog No.: PC-70157Not For Human Use, Lab Use Only.

CS-11 is a novel small molecule inhibitor that inhibits PP2A and β-catenin interaction by selectively engaging PR55α binding site (Kd=45 pM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CS-11 is a novel small molecule inhibitor that inhibits PP2A and β-catenin interaction by selectively engaging PR55α binding site (Kd=45 pM).
    CS-11 diminishes the expression of active β-Catenin and its target proteins c-Myc and cyclin D1, promotes robust E-Cadherin upregulation on the cell surface and increases β-Catenin-E-Cadherin association.
    CS-11 shows activity both in vivo tumor growth and metastasis

    Physicochemical Properties

    M.Wt 441.53
    Formula C27H27N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((E)-2-hydroxy-3-isopropyl-5-((E)-3-oxo-3-(p-tolyl)prop-1-en-1-yl)benzylidene)-N-phenylhydrazine-1-carboxamide

    References

    1. Maheshwari S, et al. Mol Cancer Ther. 2017 May 12. pii: molcanther.0584.2016.

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