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Chemical Structure : AQX-016A
Catalog No.: PC-38538Not For Human Use, Lab Use Only.
AQX-016A is a potent, selective small molecule agonist of SHIP1 phosphatase activity, upregulates SHIP1 activity in the PI3K signaling pathway in cells, without acitivty for SHIP2 phosphatase activity.
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AQX-016A is a potent, selective small molecule agonist of SHIP1 phosphatase activity, upregulates SHIP1 activity in the PI3K signaling pathway in cells, without acitivty for SHIP2 phosphatase activity.
AQX-016A decreased PI(3,4,5)P3 levels in LPS treated macrophages, but not PI3K inhibitor LY294002.
AQX-016A reduced TNFα in LPS challenged bone marrow-derived macrophages (BMDM).
| M.Wt | 328.496 | |
| Formula | C22H32O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ong CJ, et al. Blood. 2007 Sep 15;110(6):1942-9.
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