AQX-016A | SHIP1 agonist | Probechem Biochemicals

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Chemical Structure : AQX-016A

AQX-016A (AQX016A, NSC 741764)

Catalog No.: PC-38538Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AQX-016A is a potent, selective small molecule agonist of SHIP1 phosphatase activity, upregulates SHIP1 activity in the PI3K signaling pathway in cells, without acitivty for SHIP2 phosphatase activity.
AQX-016A decreased PI(3,4,5)P3 levels in LPS treated macrophages, but not PI3K inhibitor LY294002.
AQX-016A reduced TNFα in LPS challenged bone marrow-derived macrophages (BMDM).

Physicochemical Properties

M.Wt	328.496
Formula	C22H32O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(6aR,11aR,11bS)-4,4,6a,7,11b-pentamethyl-1,2,3,4a,5,6,11,11a-octahydrobenzo[a]fluorene-9,10-diol

References

1. Ong CJ, et al. Blood. 2007 Sep 15;110(6):1942-9.

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AQX-016A (AQX016A, NSC 741764)

Biological Activity

Physicochemical Properties

References

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