L598 | PTP1B/TC-PTP inhibitor | Probechem Biochemicals

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Chemical Structure : L598

L598 (PTPN1/PTPN2 inhibitor)

Catalog No.: PC-25663Not For Human Use, Lab Use Only.

L598 is a potent, hosphotyrosine mimetic dual PTPN1/PTPN2 (PTP1B/TC-PTP) inhibitor with IC50 of 120 nM for both.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

L598 is a potent, hosphotyrosine mimetic dual PTPN1/PTPN2 (PTP1B/TC-PTP) inhibitor with IC50 of 120 nM for both.
L598 is a catalytic site inhibitor of PTPN1 that can inhibit PTPN2 at an equimolar concentration.
L598 enhances CTL responses against cancer cells.
L598 synergizes with PD-1 blockade to enhance anti-tumor immunity in vivo.

Physicochemical Properties

M.Wt	362.07
Formula	C12H7BrF2NO3P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((3-bromo-7-cyanonaphthalen-2-yl)difluoromethyl)phosphonic acid

References

1. Perez-Quintero LA, et al. iScience. 2025 Sep 22;28(10):113610.

2. Yongxin Han, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3200-5.

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L598 (PTPN1/PTPN2 inhibitor)

Biological Activity

Physicochemical Properties

References

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