Chemical Structure : SHP1 agonist SCA1
CAS No.:
3087067-57-7
SHP1 agonist SCA1
Catalog No.: PC-26114Not For Human Use, Lab Use Only.
SHP1 agonist SCA1 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 36.4 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SHP1 agonist SCA1 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 36.4 uM.
SCA1 exhibits a very high degree of proteome-wide selectivity for SHP1 Cys102 at low micromolar concentrations.
SCA1 (5-40 uM) reproducibly and selectively labelled SHP1 Cys102 in THP-1 MDMs.
SCA1 could destabilize the auto-inhibited state of SHP1 and enhance SHP1 phosphatase activity.
SCA1 inhibits TLR4-driven cytokine production, inhibits LPS-induced phosphorylation at STAT3 Tyr705 and Ser727.
SCA1 inhibits production of NF-κB dependent pro-inflammatory cytokines including IL6 and TNF following LPS stimulation in a concentration-dependent manner.
SCA1 antagonizes IRAK signaling and LPS-induced pro-inflammatory cytokine production.
Physicochemical Properties
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M.Wt
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313.75
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Formula
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C15H12ClN5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-((5-chloropyrazolo[1,5-a]pyrimidin-7-yl)amino)phenyl)acrylamide
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References
1. Mei Ying Ng, et al. bioRxiv [Preprint]. 2026 Feb 22:2026.02.19.706790.
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