| Cat. No. |
Product Name |
Information |
| PC-26114 |
SHP1 agonist SCA1
SHP1 agonist
|
SHP1 agonist SCA1 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 36.4 uM. |
| PC-24886 |
Z218484536
PSPH inhibitor
|
Z218484536 is a potent and specific phosphoserine phosphatase (PSPH) inhibitor, inhibits the release of L-serine from cultured astrocytes with IC50 of 0.4 uM, reduces cellular L-serine levels with IC50 of 0.38 uM. |
| PC-24851 |
OncoACP3
ACP3 ligand
|
OncoACP3 (ProX1-(SS)) is a specific small ligand of prostatic acid phosphatase (ACP3, ACPP, PAP, PAcP) with picomolar binding affinity, shows high selectivity over placental alkaline phosphatase, TNAP and human and murine serum albumins. |
| PC-24296 |
BRD6257
PPM1D inhibitor
|
BRD6257 is a potent, selective serine/threonine phosphatase PPM1D (Wip1, PP2Cδ) inhibitor with IC50 of 5 nM in LC-MS p38 MAPK assays. |
| PC-23059 |
ABBV-CLS-579
PTP1B/PTPN2 inhibitor
|
Tegeprotafib (ABBV-CLS-579) is a potent, selective orally active PTP1B/PTPN2 inhibitor with IC50 of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively |
| PC-22917 |
DDO-3733
PP5 activator
|
DDO-3733 is a specific, small molecule, allosteric activator of serine/threonine protein phosphatase 5 (PP5) with potency of 2.9-fold PP5 activation at 50 uM, inhibits HSP90 inhibitor-induced heat shock protein expression both in cells and in vivo. |
| PC-22889 |
JAB-3312
SHP2 inhibitor
|
Sitneprotafib (JAB-3312) is a potent, selective and allosteric SHP2 inhibitor with binding Kd of 0.37 nM and enzymatic IC50 of 1.9 nM. |
| PC-22858 |
PTP4A3 inhibitor BR-1
PRL-3 inhibitor
|
PTP4A3 inhibitor BR-1 is a specfiic inhibitor of PTP4A3 (PRL-3, phosphatase of regenerating liver-3) with IC50 of 1.1 uM, selective over other 10 phosphatases, inhibits the migration and invasion of metastatic cancer cells. |
| PC-22168 |
SCP1 inhibitor GR-28
SCP1/REST inhibitor
|
SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells. |
| PC-21980 |
SBI-0802767
LMPTP inhibitor
|
SBI-0802767 is a potent, selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 239 nM, remarkably selective over class I tyrosine-specific and dual-specific PTPs. |
| PC-21979 |
LMPTP inhibitor 6g
LMPTP inhibitor
|
LMPTP inhibitor 6g is a potent, selective, uncompetitive low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 83 nM, >1000-fold selective over other phosphatases. |
| PC-21978 |
LMPTP inhibitor 5d
LMPTP inhibitor
|
LMPTP inhibitor 5d is a potent, selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 20 nM, >1000-fold selective over other phosphatases. |
