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Chemical Structure : JAB-3312
Catalog No.: PC-22889Not For Human Use, Lab Use Only.
JAB-3312 is a potent, selective and allosteric SHP2 inhibitor with binding Kd of 0.37 nM and enzymatic IC50 of 1.9 nM.
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JAB-3312 is a potent, selective and allosteric SHP2 inhibitor with binding Kd of 0.37 nM and enzymatic IC50 of 1.9 nM.
JAB-3312 is inactive in inhibiting other 22 phosphatases (including SHP1 and the PTP domain of SHP2) and 25 kinases.
JAB-3312 exhibits IC50 of 7.4 nM in KYSE-520 antiproliferation assay, and IC50 of 0.23 nM in p-ERK inhibition assay in KYSE-520 cell line.
JAB-3312 (0.1-1 mg/kg, QD, p.o.) exhibited dose-dependent antitumor effects in KYSE-520 and MV-4–11 xenograft models.
| M.Wt | 439.97 | |
| Formula | C21H22ClN7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ma C, et al. J Med Chem. 2024 Aug 7. doi: 10.1021/acs.jmedchem.4c00360.
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