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JTE-607

Chemical Structure : JTE-607

CAS No.: 188791-09-5

JTE-607 (JTE607)

Catalog No.: PC-72476Not For Human Use, Lab Use Only.

JTE-607 (JTE607) is a multiple cytokine inhibitor that potently suppresses production of proinflammatory cytokines, targets pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3).

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Biological Activity

JTE-607 (JTE607) is a multiple cytokine inhibitor that potently suppresses production of proinflammatory cytokines, targets pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3).
JTE-607 exhibits inhibitory activity on the growth of AML cell lines accompanying reduction of the proinflammatory cytokine and growth factor production.
JTE-607 suppressed expression and production of cytokines, which are spontaneously up-regulated in AML cell lines.
JTE-607 also abrogated proliferation of AML cells in a concentration range in which colony formation of normal bone marrow cells was not affected.
JTE-607 significantly prolonged survival in mice and reduced human cytokine mRNA levels in the bone marrow in leukemia model engrafted with U-937 cells.
Inhibition of CPSF3 by JTE-607 alters expression of known downstream effectors in AML and Ewing's sarcoma lines, upregulates apoptosis and causes tumor-selective stasis in mouse xenografts.
JTE-607 induces transcript accumulation and RNA Pol II read-through. CPSF3 is a core component of the pre-mRNA cleavage and polyadenylation complex.

Physicochemical Properties

M.Wt 597.36
Formula C25H33Cl4N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-Ethyl 2-(3,5-dichloro-2-hydroxy-4-(2-(4-methylpiperazin-1-yl)ethoxy)benzamido)-3-phenylpropanoate dihydrochloride

References

1. Tajima N, et al. Cancer Sci. 2010 Mar;101(3):774-81.

2. Uesato N, et al. Exp Hematol. 2006 Oct;34(10):1385-92.

3. Iwamura H, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1256-63.

4. Ross NT, et al. Nat Chem Biol. 2020 Jan;16(1):50-59.

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