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Chemical Structure : JTE-607
CAS No.: 188791-71-1
Catalog No.: PC-72476Not For Human Use, Lab Use Only.
JTE-607 (JTE607) is a multiple cytokine inhibitor that potently suppresses production of proinflammatory cytokines, targets pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $628 | In stock | |
| 1 g | Get quote |
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JTE-607 (JTE607) is a multiple cytokine inhibitor that potently suppresses production of proinflammatory cytokines, targets pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3).
JTE-607 exhibits inhibitory activity on the growth of AML cell lines accompanying reduction of the proinflammatory cytokine and growth factor production.
JTE-607 suppressed expression and production of cytokines, which are spontaneously up-regulated in AML cell lines.
JTE-607 also abrogated proliferation of AML cells in a concentration range in which colony formation of normal bone marrow cells was not affected.
JTE-607 significantly prolonged survival in mice and reduced human cytokine mRNA levels in the bone marrow in leukemia model engrafted with U-937 cells.
Inhibition of CPSF3 by JTE-607 alters expression of known downstream effectors in AML and Ewing's sarcoma lines, upregulates apoptosis and causes tumor-selective stasis in mouse xenografts.
JTE-607 induces transcript accumulation and RNA Pol II read-through. CPSF3 is a core component of the pre-mRNA cleavage and polyadenylation complex.
| M.Wt | 524.4 | |
| Formula | C25H31Cl2N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
ethyl (2S)-2-[[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]amino]-3-phenylpropanoate |
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1. Tajima N, et al. Cancer Sci. 2010 Mar;101(3):774-81.
2. Uesato N, et al. Exp Hematol. 2006 Oct;34(10):1385-92.
3. Iwamura H, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1256-63.
4. Ross NT, et al. Nat Chem Biol. 2020 Jan;16(1):50-59.
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