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Chemical Structure : BAY-091
Catalog No.: PC-72463Not For Human Use, Lab Use Only.
BAY-091 (BAY091) is a potent and highly selective inhibitor of PIP4K2A with IC50 of 16 nM in the high ATP (2 mM) HTRF assay.
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BAY-091 (BAY091) is a potent and highly selective inhibitor of PIP4K2A with IC50 of 16 nM in the high ATP (2 mM) HTRF assay.
BAY-091 showed excellent kinase selectivity profile a commercial kinase panel (Millipore, 373 kinases) at 1 uM, none of the potential off-target kinases was inhibited >60%.
BAY-091 displayed drug-like physicochemical properties with favorable lipophilicity (log D), TPSA, and aqueous solubility and exhibited high metabolic stability in human and rat liver microsomes as well as in rat hepatocytes.
BAY-091did not increase the levels of p-AKT (Ser473 and Thr308) in THP-1 cells up to a concentration of 50 uM, also was unable to induce changes in the p-PP2A (Tyr307) protein levels.
BAY-091 is a valuable chemical probe to study PIP4K2A signaling and its involvement in pathophysiological conditions such as cancer.
| M.Wt | 440.478 | |
| Formula | C26H21FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lars Wortmann, et al. J Med Chem. 2021 Nov 11;64(21):15883-15911.
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