| Cat. No. |
Product Name |
Information |
| PC-25561 |
BI 1595043
Vanin inhibitor
|
BI 1595043 is a potent, selective and orally bioavailable Vanin (vanin‐1 and vanin‐2) inhibitor, demonstrates promising effects on epithelial cell protection and reduction of inflammatory mediators in preclinical studies. |
| PC-25558 |
KCB3602
Lin28-let-7 inhibitor
|
KCB3602 is a specific small-molecule inhibitor of the Lin28–let-7 interaction with IC50 of 4.8 uM in EMSA assays, shows direct binding to Lin28a with SPR KD of 5.9 uM. |
| PC-25540 |
Ezurpimtrostat hydrochloride
PPT1 inhibitor
|
Ezurpimtrostat hydrochloride (GNS561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
| PC-25528 |
MDOLL-0286
ARH3 inhibitor
|
MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1. |
| PC-25466 |
MASTL inhibitor MKI-2
Greatwall inhibitor
|
MKI-2 (MASTL kinase inhibitor-2) is a potent small molecule inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall/GWL), inhibits recombinant MASTL activity and cellular MASTL activity with IC50 of 37.44 nM and 142.7 nM, respectively. |
| PC-25437 |
EN020
TREM2 modulator
|
EN020 is a novel small molecule modulator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 14.2 µM (MST) and 35.9 µM (SPR), significantly enhances microglial phagocytosis in BV2 cells. |
| PC-25426 |
ARN398
Acid ceramidase inhibitor
|
ARN398 is a higly potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 7 nM and 12 nM for human and rat ACDase respectively, >100-fold selective over human thymidylate synthase (h-TS). |
| PC-25425 |
ARN14988
Acid ceramidase inhibitor
|
ARN14988 is a potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 12.8 nM. |
| PC-25424 |
Pepstatin A
Aspartic protease inhibitor
|
Pepstatin A (Pepstatin) is a potent, specific, orally active aspartic protease inhibitor with IC50 of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. |
| PC-25387 |
5-O-Methylvisammioside
HMGB1 inhibitor, CNT2 inhibitor
|
5-O-Methylvisammioside (5OMV) is a flavonol compound derived from the traditional Chinese medicine plant Saposhnikovia divaricat, inhibits vasospasm induced by High Mobility Group Box 1 (HMGB1) protein, also inhibits intestinal concentrative nucleoside transporter 2 (CNT2) with IC50 of 11.22 uM, inhibits intestinal purine nucleoside absorption. |
| PC-25384 |
Acid ceramidase inhibitor 43
Acid ceramidase inhibitor
|
Acid ceramidase inhibitor 43 is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell). |
| PC-25357 |
Avicularin
FOXM1 inhibitor
|
Avicularin is a Chinese herbal medicine with anti-inflammatory and antioxidative effects, reduces cell viability and induces caspase-dependent apoptosis in NSCLC cells by facilitating USP7-dependent degradation of FOXM1. |
