ARN398 | Acid ceramidase inhibitor | Probechem Biochemicals

Chemical Structure : ARN398

ARN398 (ARN-398)

Catalog No.: PC-25426Not For Human Use, Lab Use Only.

ARN398 is a higly potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 7 nM and 12 nM for human and rat ACDase respectively, >100-fold selective over human thymidylate synthase (h-TS).

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Biological Activity

Physicochemical Properties

M.Wt	307.27
Formula	C12H16F3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hexyl-2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidine-1(2H)-carboxamide

References

1. Realini N, et al. Sci Rep. 2013;3:1035. doi: 10.1038/srep01035.

2. Realini N, et al. J Biol Chem. 2016 Jan 29;291(5):2422-34.

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ARN398 (ARN-398)

Biological Activity

Physicochemical Properties

References

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