| Cat. No. |
Product Name |
Information |
| PC-38410 |
BRD0418
TRIB1 inducer
|
BRD0418 is a specific small molecule that upregulate TRIB1 expression and phenocopy the effects of TRIB1 cDNA overexpression (EC50=1 uM, TRIB1 overexpression in HepG2 cells). |
| PC-38407 |
RJW100
LRH-1 (NR5A2) agonist
|
RJW100 (RJW 100) is a phospholipid mimetic as liver receptor homolog-1 (LRH-1, NR5A2) agonist with pEC50 of 6.6 and 7.5 for (LRH-1) and steroidogenic factor-1 (SF-1, NR5A1), respectively. |
| PC-38400 |
Inaxaplin
APOL1 inhibitor
|
Inaxaplin (VX-147, VX147) is a potent small molecule inhibitor of apolipoprotein L1 (APOL1) channel with IC50 values of 2.3 nM for APOL1 G0, 1.3 nM for APOL1 G1, and 1.1 nM for APOL1 G2, inhibits APOL1-mediated flux and cell death. |
| PC-38392 |
Farudodstat
DHODH inhibitor
|
Farudodstat (ASLAN003) is a highly potent, selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 35 nM (human DHODH), significantly inhibits protein synthesis via activation AP-1 transcription, induces cell differentiation of AML cell lines. |
| PC-38385 |
Osilodrostat
CYP11 B2 inhibitor
|
Osilodrostat (LCI 699) is a potent, orally active inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 of 2.5 and 0.7 nM, respectively. |
| PC-38384 |
Baxdrostat
CYP11 B2 inhibitor
|
Baxdrostat (CIN-107, RO6836191) is a highly potent, selective, and competitive small molecule inhibitor of aldosterone synthase (CYP11 B2, steroid 18-hydroxylase) with Ki of 13 nM, >100-fold over 11β-hydroxylase. |
| PC-38369 |
Pirepemat
cognition-promoting agent
|
Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex. |
| PC-73459 |
Abimtrelvir
Antiviral
|
Abimtrelvir is a novel antiviral agent. |
| PC-73455 |
Vutiglabridin
Insulin sensitizer
|
Vutiglabridin (HSG4112) is a synthetic structural analog of glabridin and insulin sensitizer, novel anti-obesity agent. |
| PC-73418 |
Feniralstat
Kallikrein inhibitor
|
Feniralstat (KVD-824) is a potent, selective kallikrein inhibitor with IC50 of 6.7 nM for human plasma kallikrein (pKal), dispays no inhibition against human KLKl, FXIa and Factor Xlla (IC50>40 uM). |
| PC-73396 |
CB253
r(G4C2)exp inhibitor
|
CB253 is a small molecule that selectively binds the hairpin form of r(G4C2)exp, inhibiting mechanisms that drive c9ALS/FTD pathobiology. |
| PC-73386 |
PRG-A01
SOD1 inhibitor
|
PRG-A01 is a chemical inhibitor against SOD1 misfolding and aggregation, inhibits the neuronal cell death caused by mutant-SOD1 overexpression. |
