Chemical Structure : LCL521
CAS No.: 1226851-11-1
Catalog No.: PC-38779Not For Human Use, Lab Use Only.
LCL521 is a small molecular inhibitor of acid ceramidase (ACDase), a lysosomotropic inhibitor with anticancer activity.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $278 | In stock | |
10 mg | $458 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LCL521 is a small molecular inhibitor of acid ceramidase (ACDase), a lysosomotropic inhibitor with anticancer activity.
LCL521 targets lysosomes and increases total cellular C16 ceramide level, significantly decreased myeloid-derived suppressor cell (MDSC) accumulation in vivo.
LCL521 enhances the direct tumor cell killing effect of photodynamic therapy (PDT) treatment.
M.Wt | 592.778 | |
Formula | C31H52N4O7 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
N,N-Dimethylglycine 1,1'-[(1R,2R)-1-(4-nitrophenyl)-2-[(1-oxotetradecyl)amino]-1,3-propanediyl] ester |
1. Bai A, et al. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.
2. Korbelik M, et al. Int J Cancer. 2016 Sep 15;139(6):1372-8.
3. Liu F, et al. Oncotarget. 2016 Dec 20;7(51):83907-83925.
4. Bai A, et al. PLoS One. 2017 Jun 14;12(6):e0177805.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright