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LCL521

Chemical Structure : LCL521

CAS No.: 1226851-11-1

LCL521 (1,3-di-DMG-B13)

Catalog No.: PC-38779Not For Human Use, Lab Use Only.

LCL521 is a small molecular inhibitor of acid ceramidase (ACDase), a lysosomotropic inhibitor with anticancer activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LCL521 is a small molecular inhibitor of acid ceramidase (ACDase), a lysosomotropic inhibitor with anticancer activity.
LCL521 targets lysosomes and increases total cellular C16 ceramide level, significantly decreased myeloid-derived suppressor cell (MDSC) accumulation in vivo.
LCL521 enhances the direct tumor cell killing effect of photodynamic therapy (PDT) treatment.

Physicochemical Properties

M.Wt 592.778
Formula C31H52N4O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N-Dimethylglycine 1,1'-[(1R,2R)-1-(4-nitrophenyl)-2-[(1-oxotetradecyl)amino]-1,3-propanediyl] ester

References

1. Bai A, et al. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.

2. Korbelik M, et al. Int J Cancer. 2016 Sep 15;139(6):1372-8.

3. Liu F, et al. Oncotarget. 2016 Dec 20;7(51):83907-83925.

4. Bai A, et al. PLoS One. 2017 Jun 14;12(6):e0177805.

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