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STK793590

Chemical Structure : STK793590

CAS No.: 879479-47-7

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STK793590 (DJ-1 inhibitor 15)

Catalog No.: PC-38777Not For Human Use, Lab Use Only.

STK793590 (DJ-1/PARK7 inhibitor 15) is a potent inhibitor of the Parkinson's disease associated protein DJ-1/PARK7 with Kd/IC50 of 0.1/0.28 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    STK793590 (DJ-1/PARK7 inhibitor 15) is a potent inhibitor of the Parkinson's disease associated protein DJ-1/PARK7 with Kd/IC50 of 0.1/0.28 uM, respectively.
    DJ-1/PARK7 inhibitor 15 inactivates the critical Cys106 residue of human DJ-1.
    DJ-1/PARK7 inhibitor 15 showed robust inhibitory properties in vitro and suggested inhibition of the proposed deglycase detoxifying activity of DJ-1 in cell-based assays.

    Physicochemical Properties

    M.Wt 269.275
    Formula C16H12FNO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-fluoro-1-phenethylindoline-2,3-dione

    References

    1. Shinya Tashiro, et al. ACS Chem Biol. 2018 Sep 21;13(9):2783-2793.

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