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CQ211

Chemical Structure : CQ211

CAS No.: 2648986-65-4

CQ211 (CQ-211)

Catalog No.: PC-38737Not For Human Use, Lab Use Only.

CQ211 is a potent, highly selective RIOK2 (Right open reading frame kinase 2) inhibitor with Kd of 6.1 nM, shows excellent selectivity to RIOK2 in both enzymatic and cellular assays.

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Biological Activity

CQ211 is a potent, highly selective RIOK2 (Right open reading frame kinase 2) inhibitor with Kd of 6.1 nM, shows excellent selectivity to RIOK2 in both enzymatic and cellular assays.
CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines (HT20, cell IC50=0.38 uM) and demonstrates promising in vivo efficacy in mouse xenograft models.

Physicochemical Properties

M.Wt 521.504
Formula C26H22F3N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-on

References

1. Yifan Ouyang, et al. J Med Chem. May 18, 2022.

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