| Cat. No. |
Product Name |
Information |
| PC-49203 |
IMP2 inhibitor 4
IGF2BP2 inhibitor
|
IMP2 inhibitor 4 is a small molecule inhibitor of insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2), inhibits IMP2/RNA interaction. |
| PC-49190 |
IGF2BP2 inhibitor JX5
IGF2BP2 inhibitor
|
IGF2BP2 inhibitor JX5 is a specific small-molecule inhibitor of N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) with Kd of 93.2 uM in internal fluorescence quenching measurement assays, suppresses T-ALL cells proliferation via downregulation of NOTCH1 expression. |
| PC-49181 |
ZCM-I-1
ROS modulator
|
ZCM-I-1 is a selective small molecule modulator modulator of the production of reactive oxygen species (ROS) from mitochondrial complex I, does not alter mitochondrial membrane potential and bioenergetics, selectively targets mitochondrial complex I via interactions with the IF site. |
| PC-49178 |
BDM44768
IDE inhibitor
|
BDM44768 is a potent, selective catalytic site inhibitor of insulin-degrading enzyme (IDE) with IC50 of 60 nM (hIDE). |
| PC-49176 |
Vidofludimus calcium
DHODH inhibitor
|
Vidofludimus calcium (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells. |
| PC-49175 |
IMU-838
DHODH inhibitor
|
Vidofludimus (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells. |
| PC-49150 |
CBK034026C
NAT2 inhibitor
|
CBK034026C is a small molecule targeting metabolic vulnerabilities caused by N-acetyltransferase 2 (NAT2) activity, exhibits specific toxicity towards colorectal cancer (CRC) cells with high NAT2 activity. |
| PC-49117 |
Ansornitinib
|
Ansornitinib is a dual kinase inhibitor and antifibrotic compound for treatment of fibrotic kidney diseases. |
| PC-49095 |
MFI8
Mitofusin inhibitor
|
MFI8 is a small molecule inhibitor of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively decreases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 4.8 uM. |
| PC-49094 |
MASM7
Mitofusin activator
|
MASM7 is a small molecule activator of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively increases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 75 nM, directly and specifically modulates MFN1/2 fusogenic activity. |
| PC-49093 |
NPD389
ME2 inhibitor
|
NPD389 is a potent, selective, fast-binding uncompetitive inhibitor of NADP+-dependent malic enzyme 2 (ME2) with IC50 of 4.63 uM, NPD389 is a mixed-type competitive inhibitor for the substrate L-malate and an uncompetitive inhibitor for the other substrate NAD+. |
| PC-49092 |
AS1134900
ME1 inhibitor
|
AS1134900 is a potent, highly selective, allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), uncompetitively inhibits ME1 activity in the presence of its substrates NADP+ and malate, binds outside the ME1 active site in a novel allosteric site. |
