| Cat. No. |
Product Name |
Information |
| PC-49240 |
ICMT inhibitor C75
ICMT inhibitor
|
ICMT inhibitor C75 is a potent, specific and cell-permeable inhibitor of the isoprenylcysteine carboxylmethyltransferase (ICMT) with IC50 of 0.5 uM. |
| PC-49232 |
JNJ-1289
Spermine oxidase inhibitor
|
JNJ-1289 (JNJ1289) is a potent, highly selective allosteric inhibitor of human spermine oxidase (hSMOX) with IC50 of 50 nM, inactive against hPAOX and LSD1 (IC50>2,000 nM). |
| PC-49225 |
FOXM1 inhibitor NB-73
FOXM1 inhibitor
|
FOXM1 inhibitor NB-73 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 14 nM and IC50 of 73 nM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein. |
| PC-49219 |
Kakeimide
GH3 inhibitor
|
Kakeimide is a potent GH3 inhibitor that selectively targets IAA-conjugating GH3 proteins at subnanomolar concentrations in vitro, shows auxin-like activity by inhibiting endogenous IAA catabolism. |
| PC-49211 |
TR-107
ClpP activator
|
TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement. |
| PC-49203 |
IMP2 inhibitor 4
IGF2BP2 inhibitor
|
IMP2 inhibitor 4 is a small molecule inhibitor of insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2), inhibits IMP2/RNA interaction. |
| PC-49190 |
IGF2BP2 inhibitor JX5
IGF2BP2 inhibitor
|
IGF2BP2 inhibitor JX5 is a specific small-molecule inhibitor of N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) with Kd of 93.2 uM in internal fluorescence quenching measurement assays, suppresses T-ALL cells proliferation via downregulation of NOTCH1 expression. |
| PC-49181 |
ZCM-I-1
ROS modulator
|
ZCM-I-1 is a selective small molecule modulator modulator of the production of reactive oxygen species (ROS) from mitochondrial complex I, does not alter mitochondrial membrane potential and bioenergetics, selectively targets mitochondrial complex I via interactions with the IF site. |
| PC-49178 |
BDM44768
IDE inhibitor
|
BDM44768 is a potent, selective catalytic site inhibitor of insulin-degrading enzyme (IDE) with IC50 of 60 nM (hIDE). |
| PC-49176 |
Vidofludimus calcium
DHODH inhibitor
|
Vidofludimus calcium (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells. |
| PC-49175 |
IMU-838
DHODH inhibitor
|
Vidofludimus (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells. |
| PC-49150 |
CBK034026C
NAT2 inhibitor
|
CBK034026C is a small molecule targeting metabolic vulnerabilities caused by N-acetyltransferase 2 (NAT2) activity, exhibits specific toxicity towards colorectal cancer (CRC) cells with high NAT2 activity. |
