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AGI-41998

Chemical Structure : AGI-41998

CAS No.: 2377492-26-5

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AGI-41998 (AGI 41998)

Catalog No.: PC-21474Not For Human Use, Lab Use Only.

AGI-41998 is a potent selective and brain-penetrant methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 22 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AGI-41998 is a potent selective and brain-penetrant methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 22 nM.

Physicochemical Properties

M.Wt 505.30
Formula C22H16BrF3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-

References

1. Mingzong Li, et al. J Med Chem. 2022 Mar 24;65(6):4600-4615.

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