HQY436 | CPSF3 inhibitor | Probechem Biochemicals

Chemical Structure : HQY436

HQY436 (HQY 436)

Catalog No.: PC-21417Not For Human Use, Lab Use Only.

HQY436 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.15 uM, exhibits potent antitumor activity.

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Biological Activity

HQY436 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.15 uM, exhibits potent antitumor activity.

Physicochemical Properties

M.Wt	407.28
Formula	C22H26BN3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(4-acetylpiperazin-1-yl)phenyl)-3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanamide

References

1. Shen P, et al. Sci Adv. 2023 Nov 24;9(47):eadj0123.

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HQY436 (HQY 436)

Biological Activity

Physicochemical Properties

References

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