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Chemical Structure : LY3522348
CAS No.: 2568608-48-8
Catalog No.: PC-21410Not For Human Use, Lab Use Only.
LY3522348 is a potent, highly selective, oral dual inhibitor of human ketohexokinase isoforms C and A (hKHK-C, hKHK-A) with IC50 of 20 nM and 24 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $158 | In stock | |
| 5 mg | $348 | In stock | |
| 10 mg | $548 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LY3522348 is a potent, highly selective, oral dual inhibitor of human ketohexokinase isoforms C and A (hKHK-C, hKHK-A) with IC50 of 20 nM and 24 nM, respectively.
LY3522348 potently inhibits mouse KHK-A and KHK-C enzymes with IC50 of 14 nM and 20 nM, respectively, exhibits IC50 of 41 nM in cell assay expressing hKHK.
LY3522348 shows no concerning cross-reactivity in a panel of 468 kinases as well as common profiling targets such as hERG.
LY3522348 (30-100 mg/kg PO) displays a robust pharmacodynamic response in a mouse model of fructose metabolism.
| M.Wt | 409.42 | |
| Formula | C18H22F3N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[4-[2-[(2S)-2-Methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]pyrazol-1-yl]-1-piperazin-1-yl-ethanone |
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1. Durham TB, et al. J Med Chem. 2023 Nov 22. doi: 10.1021/acs.jmedchem.3c01410.
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