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Chemical Structure : PCC0105003
Catalog No.: PC-21576Not For Human Use, Lab Use Only.
PCC0105003 is a small molecule microtubule affinity-regulating kinases (MARKs) inhibitor with IC50 of 3.0, 2.0, 2.67 and 2.67 nM for MARK1, 2, 3 and 4 repectively.
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PCC0105003 is a small molecule microtubule affinity-regulating kinases (MARKs) inhibitor with IC50 of 3.0, 2.0, 2.67 and 2.67 nM for MARK1, 2, 3 and 4 repectively.
PCC0105003 treatment partially attenuated pain-like behaviors along with improved cognitive deficit, anxiogenic-like behaviors and motor coordination in SNL rats.
PCC0105003 reversed synaptic plasticity at the functional and structural levels by suppressing NR2B/GluR1 and EB3/Drebrin signaling pathways both in amygdala and spinal dorsal horn.
| M.Wt | 419.41 | |
| Formula | C19H20F3N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yao-Qin Shi, et al. Br J Pharmacol. 2023 Dec 19. doi: 10.1111/bph.16303.
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