| Cat. No. |
Product Name |
Information |
| PC-38614 |
GPR7 antagonist 9i
GPR7 antagonist 9i
|
GPR7 antagonist 9i a highly potent antagonist of NPBWR1 (GPR7) with binding and cAMP IC50 of 0.20 and 0.86 nM for mouse GPR7, respectively. |
| PC-38613 |
GPR7 antagonist 21a
GPR7 antagonist
|
GPR7 antagonist 21a is a highly potent small molecule antagonist of NPBWR1 (GPR7) antagonist with cAMP IC50 of 30 nM, dose-dependently increased [125I]-hNPW23 dissociation rate constants from NPBWR1 in kinetic binding assays. |
| PC-38612 |
ML181
GPR7 antagonist
|
ML181 (CYM50557) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBW1) antagonist probe with IC50 of 270 nM for inhibition of NPW-induced GPR7 activation. |
| PC-38611 |
ML250
GPR7 antagonist
|
ML250 (CYM 50769) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBWR1) antagonist probe, inhibits human GPR7 expression in the presence of GPR7 agonist NPW with IC50 value of 124 nM-244 nM, displays 82- >161 fold selectivity over MCH1. |
| PC-38609 |
MYLS22
Opa1 inhibitor
|
MYLS22 is a specific, nontoxic small molecule inhibitor of the inner mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1), curtails tumor growth and metastasisin vitro and in vivo. |
| PC-38607 |
ML145
GPR35 inhibitor
|
ML145 (CID-2286812) is a selective GPR35 antagonist with IC50 of 20.1 nM, >1000-fold selectivity over GPR55. |
| PC-38606 |
CID 2745687
GPR35 inhibitor
|
CID-2745687 is a potent, selective and competitive GPR35 antagonist with pIC50 of 6.7 against human GPR35. |
| PC-38605 |
FPPS-IN-11
FPPS inhibitor
|
FPPS-IN-11 is a potent, allosteric, non-bisphosphonate farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 200 nM. |
| PC-38601 |
VK-28
Iron chelator
|
VK-28 is a novel brain permeable neuroprotective iron chelator with anti-Alzheimer's disease activities, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation with IC50 of 12.7 uM. |
| PC-38593 |
Synucleozid hydrochloride
α-synuclein inhibitor
|
Synucleozid hydrochloride (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site. |
| PC-38581 |
HyT36
Hydrophobic tag
|
HyT36 is a small-molecule hydrophobic tag compound for the degradation of stabilized proteins, induces an acute, resolvable ER stress that results in transient UPR activation without induction of apoptosis in ERHT-expressing cells. |
| PC-38576 |
ElteN378
FKBP12 inhibitor
|
ElteN378 is a highly potent synthetic inhibitor of FKBP12 with Ki of 0.5 nM, a low atomic weight ligand with affinity comparable to that of the macrolide Rapamycin |
