| Cat. No. |
Product Name |
Information |
| PC-38674 |
Ninerafaxstat
|
Ninerafaxstat (CV-8972) is a small molecule compound that promotes glucose oxidation, decreases fatty acid oxidation and improve overall mitochondrial respiration, inhibits the growth and proliferation of cancer cells. |
| PC-38668 |
JHU395
Glutamine antagonist
|
JHU395 is orally-bioavailable glutamine antagonist prodrug, shows antitumor activity in malignant peripheral nerve sheath tumor (MPNST, sNF96.2 cell growth IC50=4.6 uM). |
| PC-38667 |
(S)-IBD3540
GCPII inhibitor
|
(S)-IBD3540 is a potent, gut-restricted and orally active small molecule glutamate carboxypeptidase II (GCPII) inhibitor with IC50 of 4 nM, demonstrates anti-colitis activity in both acute and chronic mouse colitis models. |
| PC-38658 |
DS69910557
hPTHR1 antagonist
|
DS69910557 is a highly potent, selective orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist with IC50 of 0.08 uM. |
| PC-38651 |
TLK1 inhibitor J54
TLK1 inhibitor
|
TLK1 inhibitor J54 (J3-54) is a potent, small-molecule TLK1 inhibitor, induces apoptosis in AS PCa cells, suppresses growth of LNCaP xenografts combined with bicalutamide. |
| PC-38631 |
SFI003
SRSF3 inhibitor
|
SFI003 is novel serine/arginine-rich splicing factor 3 (SRSF3) inhibitor, inhibits the proliferation and migration of CRC cells, inhibits the proliferation of HCT-116 with IC50 of 8.78 uM. |
| PC-38630 |
PEPCKi
PEPCK inhibitor
|
PEPCKi is a small molecule inhibitor of hosphoenolpyruvate carboxykinase (PEPCK), blocks lactate utilization and impairs tumor growth in colorectal cancer. |
| PC-38614 |
GPR7 antagonist 9i
GPR7 antagonist 9i
|
GPR7 antagonist 9i a highly potent antagonist of NPBWR1 (GPR7) with binding and cAMP IC50 of 0.20 and 0.86 nM for mouse GPR7, respectively. |
| PC-38613 |
GPR7 antagonist 21a
GPR7 antagonist
|
GPR7 antagonist 21a is a highly potent small molecule antagonist of NPBWR1 (GPR7) antagonist with cAMP IC50 of 30 nM, dose-dependently increased [125I]-hNPW23 dissociation rate constants from NPBWR1 in kinetic binding assays. |
| PC-38612 |
ML181
GPR7 antagonist
|
ML181 (CYM50557) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBW1) antagonist probe with IC50 of 270 nM for inhibition of NPW-induced GPR7 activation. |
| PC-38611 |
ML250
GPR7 antagonist
|
ML250 (CYM 50769) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBWR1) antagonist probe, inhibits human GPR7 expression in the presence of GPR7 agonist NPW with IC50 value of 124 nM-244 nM, displays 82- >161 fold selectivity over MCH1. |
| PC-38609 |
MYLS22
Opa1 inhibitor
|
MYLS22 is a specific, nontoxic small molecule inhibitor of the inner mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1), curtails tumor growth and metastasisin vitro and in vivo. |
