ICMT inhibitor C75 | ICMT inhibitor | Probechem Biochemicals

Chemical Structure : ICMT inhibitor C75

ICMT inhibitor C75 (Isoprenylcysteine carboxylmethyltransferase inhibitor)

Catalog No.: PC-49240Not For Human Use, Lab Use Only.

ICMT inhibitor C75 is a potent, specific and cell-permeable inhibitor of the isoprenylcysteine carboxylmethyltransferase (ICMT) with IC50 of 0.5 uM.

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Biological Activity

ICMT inhibitor C75 is a potent, specific and cell-permeable inhibitor of the isoprenylcysteine carboxylmethyltransferase (ICMT) with IC50 of 0.5 uM.
C75 delays senescence and stimulates proliferation of late-passage HGPS cells and Zmpste24-deficient mouse fibroblasts.

Physicochemical Properties

M.Wt	367.533
Formula	C24H33NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-methoxy-N-(2-(2,2,6,6-tetramethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl)aniline

References

1. Judd WR, et al. Journal of Medicinal Chemistry. 2011;54:5031–5047.

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ICMT inhibitor C75 (Isoprenylcysteine carboxylmethyltransferase inhibitor)

Biological Activity

Physicochemical Properties

References

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