Catalog No.: PC-49190Not For Human Use, Lab Use Only.
IGF2BP2 inhibitor JX5 is a specific small-molecule inhibitor of N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) with Kd of 93.2 uM in internal fluorescence quenching measurement assays, suppresses T-ALL cells proliferation via downregulation of NOTCH1 expression.
IGF2BP2 inhibitor JX5 is a specific small-molecule inhibitor of N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) with Kd of 93.2 uM in internal fluorescence quenching measurement assays, suppresses T-ALL cells proliferation via downregulation of NOTCH1 expression.
JX5 showed dramatic cytotoxicity against Jurkat cells with IGF2BP2 overexpression, with minor effects on Jurkat cells transduced with IGF2BP2 shRNA. caused cell apoptosis on Jurkat cells.
JX5 has no effect on the IGF2BP2 mRNA levels but significantly down regulated the NOTCH1 expression.
JX5 (1 mg/kg or 2 mg/kg) by intraperitoneal injection impaired T-ALL expansion in T-ALL xenografts, with no overt toxicity or effect on mouse body weight and gastrointestinal system
