Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TR-107
Catalog No.: PC-49211Not For Human Use, Lab Use Only.
TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement.
TR-107 dose‐dependent increases ClpP activity, inhibits breast cancer cell MDA‐MB‐231 and SUM159 growth (IC50=23 and 12 nM) in a ClpP‐dependent manner, without a significant increase in apoptosis.
TR-107 showed significantly enhanced potency of cell growth inhibition in the MDA‐MB‐231 and SUM159 cell models compared with ONC201 and ONC206.
TR‐107 (100 nM, 6-24 h) induces time‐ and dose‐dependent reduction of multiple mitochondrial proteins (TUFM and TFAM, aconitase (ACO2) and isocitrate dehydrogenase (IDH2), and succinate dehydrogenase A (SDHA) and complex I subunit NDUFS3).
TR‐107 reduces mitochondrial metabolic functions and inhibits OXPHOS in MDA‐MB‐231 cells.
TR‐107 (4-8 mg/kg, p.o.) prevents tumor growth in MDA‐MB‐231 xenograft model.
| M.Wt | 390.871 | |
| Formula | C22H19ClN4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Fennell EMJ, et al. Pharmacol Res Perspect. 2022 Aug;10(4):e00993.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
