| Cat. No. |
Product Name |
Information |
| PC-35852 |
SGC-GAK-1
GAK inhibitor
|
SGC-GAK-1 (GAK inhibitor 1) is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki of 3.2 nM, 16,000-fold selectivity over NAK. |
| PC-35840 |
AB680
CD73 inhibitor
|
AB680 (Quemliclustat) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73). |
| PC-35831 |
PZ-2891
PANK modulator
|
PZ-2891 (PZ2891) a specific, allosteric, BBB-permeable, orally active Pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM, hPANK3) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA in biochemical assays. |
| PC-35829 |
QM385
Sepiapterin reductase inhibitor
|
QM385 (QM-385) is an orally available, potent, specific sepiapterin reductase (SPR) inhibitor (binding IC50=1.49 nM) to limit tetrahydrobiopterin (BH4) production, effectively inhibits the proliferation of human CD4+ T cells. |
| PC-35824 |
GOT1 inhibitor 2c
GOT1 inhibitor
|
GOT1 inhibitor 2c is a first-in-class, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM.. |
| PC-35823 |
iGOT1-01
|
iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM. |
| PC-35821 |
AF40431
Sortilin ligand
|
AF40431 (AF-40431) is the first reported small-molecule ligand of the VPS10P family sorting receptor Sortilin with IC50 of 4.4 uM, binds in the neurotensin-binding site of sortilin.. |
| PC-35817 |
Malic Enzyme inhibitor ME1
Malic enzyme ME1 inhibitor
|
Malic Enzyme inhibitor ME1 (ME1) is a small molecule inhibitor of Malic Enzyme (ME1) with IC50 of 0.15 uM. |
| PC-35807 |
OGG1 inhibitor O8
OGG1 inhibitor
|
OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM). |
| PC-35789 |
NSC 146268
CD151 inhibitor
|
NSC 146268 (NSC146268, 6-Aza-2-thiouridine) is a novel small molecule inhibitor of CD151, inhibits proliferation of metastatic triple negative breast cancer cell lines (MDA-MB 231 and MDA-MB 468, IC50 of 6.0 and 6.2 ug/mL). |
| PC-35767 |
APA modulator T5
Alternative polyadenylation modulator
|
APA modulator T5 is a small modulator of alternative polyadenylation (APA), modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts. |
| PC-35766 |
APA modulator T4
Alternative polyadenylation modulator
|
APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts. |
