| Cat. No. |
Product Name |
Information |
| PC-72845 |
PTI-125
Filamin A corrector
|
PTI-125 (Simufilam, Sumifilam) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation. |
| PC-72843 |
RAGE229
RAGE inhibitor
|
RAGE229 (RAGE-229) is a specific antagonist of ctRAGE-DIAPH1 interaction, high potently binds to cytoplasmic tail of RAGE (ctRAGE) with KD of 2 nM. |
| PC-72839 |
BOS-318
Furin inhibitor
|
BOS-318 (BOS318) is a potent, highly selective, cell-permeable furin inhibitor with IC50 of 1.9 nM, Ki of 0.4 nM. |
| PC-72838 |
KM04794
UPR inhibitor
|
KM04794 (KM-04794) is a chemical chaperone-like small molecule modulator of endoplasmic reticulum (ER) proteostasis and alleviates ER stress, inhibits UPR signaling with IC50 of 10 uM. |
| PC-72833 |
ChemR23 inhibitor 14f
ChemR23 inhibitor
|
ChemR23 inhibitor 14f is a potent and orally active inhibitor of ChemR23 (IC80=12 nM), a G protein-coupled receptor (GPCR) expressed on the surface of plasmacytoid dendritic cells (pDCs). |
| PC-72831 |
Nek1 inhibitor 10f
Nek1 inhibitor
|
Nek1 inhibitor 10f is a potent, selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 330 nM. |
| PC-72819 |
SID7969543
SF-1/NR5A1 inhibitor
|
SID7969543 is a potent, selective and cell penetrant inhibitor of steroidogenic factor 1 (SF-1/NR5A1) with IC50 of 760 nM, also selectively targets KMT2A-rearranged (KMT2A-r) leukemia cells. |
| PC-72817 |
BACH2 inhibitor compound 8
BACH2/BACH1 inhibitor
|
BACH2 inhibitor compound 8 is a potent, dual BACH2/BACH1 inhibitor. |
| PC-72813 |
SOCS1 inhibitor 20
SOCS1 inhibitor
|
SOCS1 inhibitor 20 is a specific, cell-permeable phosphotyrosine peptide that target the SH2 domain of SOCS1 (Suppressor of cytokine signaling 1) with IC50 of 20 nM (hSOCS1) |
| PC-72812 |
TLX agonist 10
TLX (NR2E1) agonist
|
TLX agonist 10 is potent, selective agonist of the orphan nuclear receptor tailless homologue (TLX, NR2E1) with pEC50 of 6.6. |
| PC-72801 |
HB007
SUMO1 degrader
|
HB007 (HB-007) is a small-molecule degrader of the small ubiquitin-related modifier 1 (SUMO1) with anticancer potency in vitro and in vivo. |
| PC-72788 |
S62798
TAFIa inhibitor
|
S62798 (S 62798) is a highly selective human, mouse and rat TAFIa (Thrombin Activatable Fibrinolysis Inhibitor) inhibitor with IC50 of 11, 270, 178 nM respectively. |
