Cat. No. |
Product Name |
Information |
PC-49741 |
Compound 7930079
Troponin C modulator
|
Compound 7930079 is a small molecule that increase calcium sensitivity without altering systolic calcium concentration and strengthening cardiac function, is a high affinity binder of Troponin C N-terminal domain (cNTnC) with Kd of 1.45 uM. |
PC-49740 |
BI-6c9
Bid inhibitor
|
BI-6C9 is a specific small molecule inhibitor of BH3 interacting-domain death agonist (Bid) with Kd of 20 uM, blocks the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. |
PC-49739 |
MS0621
EWSR1::FLI1 modulator
|
MS0621 (UNC0621, MS 0621) is a small-molecule modulator of EWSR1::FLI1-mediated chromatin, reverses EWSR1::FLI1-mediated chromatin accessibility, persistently and selectively inhibits cell proliferation in Ewing sarcoma cell lines (SK-N-MC, IC50=128 nM). |
PC-49731 |
trans-MiM111
Mitofusin activator
|
trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93). |
PC-49730 |
CPR1-B
Mitofusin activator
|
CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%). |
PC-49726 |
Seletracetam
SV2A ligand
|
Seletracetam (ucb 44212) is a high affinity for the synaptic vesicle protein 2A (SV2A) than levetiracetam with 10-fold, exhibits anticonvulsant properties in animal models of epilepsy. |
PC-49704 |
NUP-17d-52A
Plek2 inhibitor
|
NUP-17d-52A (Plek2 inhibitor) is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2-DEP domain with high affinity (Kd=160 nM). |
PC-49703 |
Plek2 inhibitor NUP-17d
Plek2 inhibitor
|
Plek2 inhibitor NUP-17d is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2 and Plek2-DEP with high affinity (ITC KD=109 and 350 nM, respectively). |
PC-49693 |
Xist inhibitor X1
Xist inhibitor
|
Xist inhibitor X1 is a selective small molecule inhibitor of the non-coding RNA prototype Xist function, binds specifically to the RepA motif of Xist (Kd=0.4 uM) in vitro and in vivo. |
PC-49690 |
Novobiocin
POLθ inhibitor
|
Novobiocin (NVB) is a potent, specific DNA polymerase theta (POLθ, POLQ) inhibitor with IC50 of 24 uM, selectively kills HR-deficient tumor cells in vitro and in vivo. |
PC-49685 |
MPO inhibitor IN-4
MPO inhibitor
|
MPO inhibitor IN-4 is a highly potent, selective, irreversible and orally bioavailable myeloperoxidase (MPO) inhibitor. |
PC-49645 |
TH8535
OGG1 inhibitor
|
TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM. |