Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Methyl Gerfelin
Catalog No.: PC-62074Not For Human Use, Lab Use Only.
Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM.
Methyl Gerfelin inhibits osteoclast differentiation, suppresses osteoclastogenesis with no influence on the phagocytic ability of BMMs.
Methyl Gerfelin significantly increases intracellular methylglyoxal (MG) levels in BMMs.
Methyl Gerfelin also inhibits P. falciparum GLO1.
| M.Wt | 304.298 | |
| Formula | C16H16O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kawatani M, et al. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11691-6.
2. Urscher M, et al. Mol Microbiol. 2010 Apr;76(1):92-103.
3. Kanoh N, et al. Bioconjug Chem. 2013 Jan 16;24(1):44-52.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
