Methyl Gerfelin | Glyoxalase I inhibitor

Chemical Structure : Methyl Gerfelin

Methyl Gerfelin (GLO1 inhibitor, Glyoxalase I inhibitor)

Catalog No.: PC-62074Not For Human Use, Lab Use Only.

Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM.

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Biological Activity

Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM.
Methyl Gerfelin inhibits osteoclast differentiation, suppresses osteoclastogenesis with no influence on the phagocytic ability of BMMs.
Methyl Gerfelin significantly increases intracellular methylglyoxal (MG) levels in BMMs.
Methyl Gerfelin also inhibits P. falciparum GLO1.

Physicochemical Properties

M.Wt	304.298
Formula	C16H16O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate

References

1. Kawatani M, et al. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11691-6.

2. Urscher M, et al. Mol Microbiol. 2010 Apr;76(1):92-103.

3. Kanoh N, et al. Bioconjug Chem. 2013 Jan 16;24(1):44-52.

Methyl Gerfelin (GLO1 inhibitor, Glyoxalase I inhibitor)

Biological Activity

Physicochemical Properties

References

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