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Chemical Structure : ML387
Catalog No.: PC-62124Not For Human Use, Lab Use Only.
ML387 (CID3474778) is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 19 nM.
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ML387 (CID3474778) is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 19 nM.
ML387 dispalys 71-fold selectivity versus ALDH1A1, and >1,000 fold versus LDHA, LDHB, rGAPDH, and HSD17B4.
ML387 potently promotes PGE2 production in both A549 lung cancer and LNCaP prostate cancer cells.
| M.Wt | 449.43 | |
| Formula | C22H22F3N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Duveau DY, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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