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ML387

Chemical Structure : ML387

CAS No.: 1537193-19-3

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ML387 (CID3474778)

Catalog No.: PC-62124Not For Human Use, Lab Use Only.

ML387 (CID3474778) is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 19 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML387 (CID3474778) is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 19 nM.
    ML387 dispalys 71-fold selectivity versus ALDH1A1, and >1,000 fold versus LDHA, LDHB, rGAPDH, and HSD17B4.
    ML387 potently promotes PGE2 production in both A549 lung cancer and LNCaP prostate cancer cells.

    Physicochemical Properties

    M.Wt 449.43
    Formula C22H22F3N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1-(4-methoxyphenyl)-1H-benzo[d]imidazol-5-yl)(piperidin-1-yl)methanone 2,2,2-trifluoroacetic acid

    References

    1. Duveau DY, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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