Chemical Structure : FSC231
CAS No.: 1215849-96-9
Catalog No.: PC-62059Not For Human Use, Lab Use Only.
FSC231 (FSC-231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM.
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
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FSC231 (FSC-231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM.
FSC231 inhibits the interaction between GluR2 and PICK1, accelerates recycling of pHluorin-tagged GluR2 in hippocampal neurons.
FSC231 blocks the expression of both long-term depression and long-term potentiation in rats and murine hippocampal neurons.
| M.Wt | 313.134 | |
| Formula | C13H10Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-ethyl 2-cyano-3(3,4-dichlorophenyl)acryloylcarbamate |
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1. Thorsen TS, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8.
2. Qiu CY, et al. J Neuroinflammation. 2012 May 29;9:108.
3. Herbert LM, et al. Am J Physiol Cell Physiol. 2016 Mar 1;310(5):C390-400.

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