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Cat. No. Product Name Information
PC-49115

NX-13

NLRX1 agonist

NX-13 (Amelenodor) is an orally active, gut-restricted NLRX1 agonist, has in situ binding effects on the stability of NLRX1 with EC50 of 58 nM.
PC-49095

MFI8

Mitofusin inhibitor

MFI8 (Mitochondrial Fusion Inhibitor 8) is a small molecule inhibitor of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively decreases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 4.8 uM.
PC-49094

MASM7

Mitofusin activator

MASM7 is a small molecule activator of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively increases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 75 nM, directly and specifically modulates MFN1/2 fusogenic activity.
PC-49093

NPD389

ME2 inhibitor

NPD389 is a potent, selective, fast-binding uncompetitive inhibitor of NADP+-dependent malic enzyme 2 (ME2) with IC50 of 4.63 uM, NPD389 is a mixed-type competitive inhibitor for the substrate L-malate and an uncompetitive inhibitor for the other substrate NAD+.
PC-49092

AS1134900

ME1 inhibitor

AS1134900 is a potent, highly selective, allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), uncompetitively inhibits ME1 activity in the presence of its substrates NADP+ and malate, binds outside the ME1 active site in a novel allosteric site.
PC-49091

RKN5755

β-arrestin1 ligand

RKN5755 is a small-molecule ligand of β-arrestin1, inhibits the enhanced migration of fibroblasts cocultured with cancer cells by binding to β-arrestin1 and interfering with β-arrestin1-mediated cofilin signaling pathways.
PC-49090

MCI-100

MCI-100 is a small molecule that displays greater potency than sulindac to protect RPE cells against oxidative damage, with lacked significant COX inhibitory activity, MCI-100 is more active than sulindac in protecting cells against oxidative damage.
PC-49085

ASR352

ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells.
PC-49043

NP-C86

GAS5 modulator

NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo.
PC-49041

CD147 inhibitor AC-73

CD147 inhibitor

AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells.
PC-49031

PSB-CB-148

GPR18 antagonist

PSB-CB-148 is a potent, selective antagonist of GPR18.
PC-49030

PSB-KD107

GPR18 agonist

PSB-KD107 is a potent, selective GPR18 receptor agonist with EC50 of 0.562 uM and 1.78 uM for human and mouse GPR18, respectively.

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