| Cat. No. |
Product Name |
Information |
| PC-49245 |
DDX3X helicase inhibitor 64
DDX3X inhibitor
|
DDX3X helicase inhibitor 64 is a potent, selective inhibitor of DDX3X helicase activity with IC50 of 0.14 μM, shows promising anti-HCV activity, with an EC50 of 0.2 μM and cytotoxicity of 86 μM. |
| PC-49243 |
FHP01
DDX3X inhibitor
|
FHP01 (BA103) is a potent, small molecule inhibitor of DDX3X helicase activity with IC50 of 0.3 uM in in vitro enzyme assays, exhibits very effective antiproliferative and killing activity against different breast cancer cell types (IC50=3.058 and 3.21 μM in MDA MB 468 and MDA MB 231, respectively). |
| PC-49242 |
TPC2-A1-P
TPC2 agonist
|
TPC2-A1-P is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 10.5 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium. |
| PC-49241 |
TPC2-A1-N
TPC2 agonist
|
TPC2-A1-N is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 7.8 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium. |
| PC-49240 |
ICMT inhibitor C75
ICMT inhibitor
|
ICMT inhibitor C75 is a potent, specific and cell-permeable inhibitor of the isoprenylcysteine carboxylmethyltransferase (ICMT) with IC50 of 0.5 uM. |
| PC-49232 |
JNJ-1289
Spermine oxidase inhibitor
|
JNJ-1289 (JNJ1289) is a potent, highly selective allosteric inhibitor of human spermine oxidase (hSMOX) with IC50 of 50 nM, inactive against hPAOX and LSD1 (IC50>2,000 nM). |
| PC-49225 |
FOXM1 inhibitor NB-73
FOXM1 inhibitor
|
FOXM1 inhibitor NB-73 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 14 nM and IC50 of 73 nM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein. |
| PC-49219 |
Kakeimide
GH3 inhibitor
|
Kakeimide is a potent GH3 inhibitor that selectively targets IAA-conjugating GH3 proteins at subnanomolar concentrations in vitro, shows auxin-like activity by inhibiting endogenous IAA catabolism. |
| PC-49211 |
TR-107
ClpP activator
|
TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement. |
| PC-49203 |
IMP2 inhibitor 4
IGF2BP2 inhibitor
|
IMP2 inhibitor 4 is a small molecule inhibitor of insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2), inhibits IMP2/RNA interaction. |
| PC-49190 |
IGF2BP2 inhibitor JX5
IGF2BP2 inhibitor
|
IGF2BP2 inhibitor JX5 is a specific small-molecule inhibitor of N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) with Kd of 93.2 uM in internal fluorescence quenching measurement assays, suppresses T-ALL cells proliferation via downregulation of NOTCH1 expression. |
| PC-49181 |
ZCM-I-1
ROS modulator
|
ZCM-I-1 is a selective small molecule modulator modulator of the production of reactive oxygen species (ROS) from mitochondrial complex I, does not alter mitochondrial membrane potential and bioenergetics, selectively targets mitochondrial complex I via interactions with the IF site. |
