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Chemical Structure : DS07551382
Catalog No.: PC-49675Not For Human Use, Lab Use Only.
DS07551382 (DS 07551382) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1), suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2.
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DS07551382 (DS 07551382) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1), suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2.
DS07551382 strongly suppressed the de novo PS synthesis in PTDSS2-KO HCT116 clone, whereas they weakly suppressed it in parental HCT116.
DS07551382 inhibits PS synthesis and induces ER stress in PTDSS2-deleted tumor cells.
| M.Wt | 554.91 | |
| Formula | C27H18ClF3N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yohei Yoshihama, et al. Cancer Res. 2022 Nov 2;82(21):4031-4043.
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