Catalog No.: PC-49675Not For Human Use, Lab Use Only.
DS07551382 (DS 07551382) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1), suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2.
DS07551382 (DS 07551382) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1), suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2.
DS07551382 strongly suppressed the de novo PS synthesis in PTDSS2-KO HCT116 clone, whereas they weakly suppressed it in parental HCT116.
DS07551382 inhibits PS synthesis and induces ER stress in PTDSS2-deleted tumor cells.
